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c 176  (MedChemExpress)


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    Structured Review

    MedChemExpress c 176
    SIRT3 Mediates the Protective Effects of JQ1 Against CGAS/STING Activation and Ferroptosis Following OGD. ( A ) Representative Western blot images of SIRT3, cGAS, and STING expression in HT22 cells. ( B ) Representative images of immunofluorescence staining for STING (green) and DAPI (blue) in HT22 cells of each group. Scale bar = 25μm. ( C ) Representative images of immunofluorescence staining for cGAS (green) and DAPI (blue) in HT22 cells of each group. Scale bar = 25μm. ( D – G ) Representative Western blot images and quantification of SLC3A2, SLC7A11, and GPX4 expression (normalized to β-Actin) in HT22 cells. ( H – K ) Representative Western blot images and quantification of STING, SLC7A11, and GPX4 expression (normalized to β-Actin) in HT22 cells. Data are expressed as mean ± SD independent replicates: ns: not significant; ###P < 0.001 versus Control group; *P < 0.05, **P < 0.01, ***P < 0.001 versus OGD+JQ1+si-NC group; @P < 0.05, @@P < 0.01, @@@P < 0.001 versus OGD <t>+C-176</t> group; &P < 0.05 versus OGD+JQ1 group.
    C 176, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 96/100, based on 134 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/c 176/product/MedChemExpress
    Average 96 stars, based on 134 article reviews
    c 176 - by Bioz Stars, 2026-04
    96/100 stars

    Images

    1) Product Images from "(+)-JQ1 Upregulates SIRT3 to Suppress cGAS/STING Pathway-Mediated Neuronal Inflammation and Ferroptosis After Hypoxic-Ischemic Encephalopathy"

    Article Title: (+)-JQ1 Upregulates SIRT3 to Suppress cGAS/STING Pathway-Mediated Neuronal Inflammation and Ferroptosis After Hypoxic-Ischemic Encephalopathy

    Journal: Drug Design, Development and Therapy

    doi: 10.2147/DDDT.S578815

    SIRT3 Mediates the Protective Effects of JQ1 Against CGAS/STING Activation and Ferroptosis Following OGD. ( A ) Representative Western blot images of SIRT3, cGAS, and STING expression in HT22 cells. ( B ) Representative images of immunofluorescence staining for STING (green) and DAPI (blue) in HT22 cells of each group. Scale bar = 25μm. ( C ) Representative images of immunofluorescence staining for cGAS (green) and DAPI (blue) in HT22 cells of each group. Scale bar = 25μm. ( D – G ) Representative Western blot images and quantification of SLC3A2, SLC7A11, and GPX4 expression (normalized to β-Actin) in HT22 cells. ( H – K ) Representative Western blot images and quantification of STING, SLC7A11, and GPX4 expression (normalized to β-Actin) in HT22 cells. Data are expressed as mean ± SD independent replicates: ns: not significant; ###P < 0.001 versus Control group; *P < 0.05, **P < 0.01, ***P < 0.001 versus OGD+JQ1+si-NC group; @P < 0.05, @@P < 0.01, @@@P < 0.001 versus OGD +C-176 group; &P < 0.05 versus OGD+JQ1 group.
    Figure Legend Snippet: SIRT3 Mediates the Protective Effects of JQ1 Against CGAS/STING Activation and Ferroptosis Following OGD. ( A ) Representative Western blot images of SIRT3, cGAS, and STING expression in HT22 cells. ( B ) Representative images of immunofluorescence staining for STING (green) and DAPI (blue) in HT22 cells of each group. Scale bar = 25μm. ( C ) Representative images of immunofluorescence staining for cGAS (green) and DAPI (blue) in HT22 cells of each group. Scale bar = 25μm. ( D – G ) Representative Western blot images and quantification of SLC3A2, SLC7A11, and GPX4 expression (normalized to β-Actin) in HT22 cells. ( H – K ) Representative Western blot images and quantification of STING, SLC7A11, and GPX4 expression (normalized to β-Actin) in HT22 cells. Data are expressed as mean ± SD independent replicates: ns: not significant; ###P < 0.001 versus Control group; *P < 0.05, **P < 0.01, ***P < 0.001 versus OGD+JQ1+si-NC group; @P < 0.05, @@P < 0.01, @@@P < 0.001 versus OGD +C-176 group; &P < 0.05 versus OGD+JQ1 group.

    Techniques Used: Activation Assay, Western Blot, Expressing, Immunofluorescence, Staining, Control



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    SIRT3 Mediates the Protective Effects of JQ1 Against CGAS/STING Activation and Ferroptosis Following OGD. ( A ) Representative Western blot images of SIRT3, cGAS, and STING expression in HT22 cells. ( B ) Representative images of immunofluorescence staining for STING (green) and DAPI (blue) in HT22 cells of each group. Scale bar = 25μm. ( C ) Representative images of immunofluorescence staining for cGAS (green) and DAPI (blue) in HT22 cells of each group. Scale bar = 25μm. ( D – G ) Representative Western blot images and quantification of SLC3A2, SLC7A11, and GPX4 expression (normalized to β-Actin) in HT22 cells. ( H – K ) Representative Western blot images and quantification of STING, SLC7A11, and GPX4 expression (normalized to β-Actin) in HT22 cells. Data are expressed as mean ± SD independent replicates: ns: not significant; ###P < 0.001 versus Control group; *P < 0.05, **P < 0.01, ***P < 0.001 versus OGD+JQ1+si-NC group; @P < 0.05, @@P < 0.01, @@@P < 0.001 versus OGD <t>+C-176</t> group; &P < 0.05 versus OGD+JQ1 group.
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    SIRT3 Mediates the Protective Effects of JQ1 Against CGAS/STING Activation and Ferroptosis Following OGD. ( A ) Representative Western blot images of SIRT3, cGAS, and STING expression in HT22 cells. ( B ) Representative images of immunofluorescence staining for STING (green) and DAPI (blue) in HT22 cells of each group. Scale bar = 25μm. ( C ) Representative images of immunofluorescence staining for cGAS (green) and DAPI (blue) in HT22 cells of each group. Scale bar = 25μm. ( D – G ) Representative Western blot images and quantification of SLC3A2, SLC7A11, and GPX4 expression (normalized to β-Actin) in HT22 cells. ( H – K ) Representative Western blot images and quantification of STING, SLC7A11, and GPX4 expression (normalized to β-Actin) in HT22 cells. Data are expressed as mean ± SD independent replicates: ns: not significant; ###P < 0.001 versus Control group; *P < 0.05, **P < 0.01, ***P < 0.001 versus OGD+JQ1+si-NC group; @P < 0.05, @@P < 0.01, @@@P < 0.001 versus OGD <t>+C-176</t> group; &P < 0.05 versus OGD+JQ1 group.
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    SIRT3 Mediates the Protective Effects of JQ1 Against CGAS/STING Activation and Ferroptosis Following OGD. ( A ) Representative Western blot images of SIRT3, cGAS, and STING expression in HT22 cells. ( B ) Representative images of immunofluorescence staining for STING (green) and DAPI (blue) in HT22 cells of each group. Scale bar = 25μm. ( C ) Representative images of immunofluorescence staining for cGAS (green) and DAPI (blue) in HT22 cells of each group. Scale bar = 25μm. ( D – G ) Representative Western blot images and quantification of SLC3A2, SLC7A11, and GPX4 expression (normalized to β-Actin) in HT22 cells. ( H – K ) Representative Western blot images and quantification of STING, SLC7A11, and GPX4 expression (normalized to β-Actin) in HT22 cells. Data are expressed as mean ± SD independent replicates: ns: not significant; ###P < 0.001 versus Control group; *P < 0.05, **P < 0.01, ***P < 0.001 versus OGD+JQ1+si-NC group; @P < 0.05, @@P < 0.01, @@@P < 0.001 versus OGD <t>+C-176</t> group; &P < 0.05 versus OGD+JQ1 group.
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    Image Search Results


    SIRT3 Mediates the Protective Effects of JQ1 Against CGAS/STING Activation and Ferroptosis Following OGD. ( A ) Representative Western blot images of SIRT3, cGAS, and STING expression in HT22 cells. ( B ) Representative images of immunofluorescence staining for STING (green) and DAPI (blue) in HT22 cells of each group. Scale bar = 25μm. ( C ) Representative images of immunofluorescence staining for cGAS (green) and DAPI (blue) in HT22 cells of each group. Scale bar = 25μm. ( D – G ) Representative Western blot images and quantification of SLC3A2, SLC7A11, and GPX4 expression (normalized to β-Actin) in HT22 cells. ( H – K ) Representative Western blot images and quantification of STING, SLC7A11, and GPX4 expression (normalized to β-Actin) in HT22 cells. Data are expressed as mean ± SD independent replicates: ns: not significant; ###P < 0.001 versus Control group; *P < 0.05, **P < 0.01, ***P < 0.001 versus OGD+JQ1+si-NC group; @P < 0.05, @@P < 0.01, @@@P < 0.001 versus OGD +C-176 group; &P < 0.05 versus OGD+JQ1 group.

    Journal: Drug Design, Development and Therapy

    Article Title: (+)-JQ1 Upregulates SIRT3 to Suppress cGAS/STING Pathway-Mediated Neuronal Inflammation and Ferroptosis After Hypoxic-Ischemic Encephalopathy

    doi: 10.2147/DDDT.S578815

    Figure Lengend Snippet: SIRT3 Mediates the Protective Effects of JQ1 Against CGAS/STING Activation and Ferroptosis Following OGD. ( A ) Representative Western blot images of SIRT3, cGAS, and STING expression in HT22 cells. ( B ) Representative images of immunofluorescence staining for STING (green) and DAPI (blue) in HT22 cells of each group. Scale bar = 25μm. ( C ) Representative images of immunofluorescence staining for cGAS (green) and DAPI (blue) in HT22 cells of each group. Scale bar = 25μm. ( D – G ) Representative Western blot images and quantification of SLC3A2, SLC7A11, and GPX4 expression (normalized to β-Actin) in HT22 cells. ( H – K ) Representative Western blot images and quantification of STING, SLC7A11, and GPX4 expression (normalized to β-Actin) in HT22 cells. Data are expressed as mean ± SD independent replicates: ns: not significant; ###P < 0.001 versus Control group; *P < 0.05, **P < 0.01, ***P < 0.001 versus OGD+JQ1+si-NC group; @P < 0.05, @@P < 0.01, @@@P < 0.001 versus OGD +C-176 group; &P < 0.05 versus OGD+JQ1 group.

    Article Snippet: To inhibit STING, the cells were pre-stimulated with 1 μM C-176 (HY-112906, MedChemExpress, China) before cultured in hypoxic condition.

    Techniques: Activation Assay, Western Blot, Expressing, Immunofluorescence, Staining, Control